Lactoferrin

Lactoferrin (LTF) is found in secretory fluids. It is a component of the immune system and has antimicrobial activity. LTF interacts with DNA, RNA, polysaccharides and heparin. LTF is inhibited by nonsteroidal anti-inflammatory drugs (NSAID) like aspirin. For detailed discussion of human lactoferrin see Human lactoferrin.

Apo lactoferrin
1i6b, 1b7u – hoLTF – horse 1dtz – cLTF - camel 1cb6, 1lfg, 1lfh – hLTF - human 1u62, 1xv4, 1xv7 - hLTF peptide – NMR

Lactoferrin
1blf – bLTF + 2Fe – bovine 1sdx - bLTF C lobe + 3Zn 1nkx - bLTF C lobe + 2Zn + 2Fe

1b1x – hoLTF + 2Fe

1qjm – hoLTF + 2Sm 1ce2, 1biy – buLTF + 2Fe - buffalo 1i6q – cLTF + 2Fe

2bjj, 1sqy, 1n76– hLTF + 2Fe

1b0l - hLTF (mutant) + 2Fe

1fck – hLTF + 2Ce 1lfi - hLTF + 2Cu 1lct - hLTF N lobe + 2Fe

1h43, 1h44, 1h45, 1l5t, 1eh3, 1vfd, 1vfe, 1hse, 1dsn - hLTF N lobe (mutant) + 2Fe

1jw1 – LTF + 2Fe – goat

Lactoferrin binary complex
3sdf – bLTF C lobe + lipoteichoic acid + 2Zn + 2Fe

3rgy - bLTF C lobe + lipopolysaccharide + Zn + 2Fe

3kj7, 3k0v, 2q8j, 2o51, 2nwj, 2dxy, 2dwj, 2dsf, 2ds9, 2hca, 2dqv, 2dp8, 2g93, 2ays - bLTF C lobe + polysaccharide + 2Zn + 2Fe

2o1l - bLTF C lobe + polysaccharide + Zn + Fe 2fa7, 2b65 - bLTF C lobe + polysaccharide + 3Zn + Fe 3iaz, 3ib0, 3ib1 - bLTF C lobe (mutant) + NSAID + 2Zn + 2Fe

3e9x, 2qje, 2zmb, 3crb, 2nuv - bLTF C lobe + NSAID + 2Zn + 2Fe

3o97, 3mjn, 3cfl, 2ocu – bLTF C lobe + inhibitor + 2Zn + 2Fe

3ib2 - bLTF C lobe (mutant) + inhibitor + 2Zn + 2Fe

2doj - bLTF C lobe + adenosine + 2Zn + 2Fe

3ci8 - bLTF C lobe + niacin + 2Zn + 2Fe

2r9j - bLTF C lobe + nicotinamide + 2Zn + 2Fe

2r71 - bLTF C lobe + inositol + 2Zn + 2Fe

3ptl – bLTF peptide + proteinase K 1bjr - buLTF peptide + proteinase K 1b7z - hoLTF + 2Fe + oxalate 3cr9 – hoLTF + inhibitor + 2Fe

2j4u – cLTF N terminal + OMPC  1bka - hLTF + 2Fe + oxalate<BR /> 1lcf - hLTF + 2Cu + oxalate<BR /> 2pms – hLTF N lobe + PSPA transferring-binding domain + 2Zn + 2Fe